Mliri wasintha dziko.Padziko lonse lapansi, maboma amayiko onse akukumana ndi zovuta zazikulu pakupewa ndi kuwongolera miliri.Panthawi ya mliri wa COVID-19, China ili m'magawo anayi a njira zopewera ndi kuyankha (kupewa, kuzindikira, kuwongolera ndi Chinsinsi chakuchita bwino chikuwonetsedwa pachithandizo).Ndipo kudzera muzofalitsa ndi chithandizo chamankhwala kufalitsa zomwe zachitika ku China padziko lonse lapansi.Komabe, chifukwa chazifukwa zambiri monga chipembedzo, demokalase, zizolowezi zachigawo, ndi kusintha kwa ma virus, mliri wapadziko lonse lapansi sunalamuliridwe bwino, ndipo kuchuluka kwa milandu yotsimikizika ndi kufa kwakula kwambiri.
Atalowa mu Marichi 2021, mliri wapadziko lonse lapansi womwe udakhazikika pang'onopang'ono, chifukwa cha bomba lomwe lidachitika ku India, unaphulikanso!Mwa njira, korona watsopano wapadziko lonse lapansi wabweretsedwa mu mliri wachitatu.Malinga ndi zidziwitso zomwe zatulutsidwa ndi World Health Organisation, kuyambira koyambirira kwa Epulo, kuchuluka kwa milandu yatsopano ku India kwakwera pafupifupi, ndipo kwadutsa 400,000 nthawi ya 26.Ndipo ndi chiwerengero chonse cha milandu yotsimikizika ya 1.838 miliyoni, idakhala dera lachiwiri lomwe lakhudzidwa kwambiri padziko lonse lapansi pambuyo pa United States.

Koma izi siziri zochitika zonse, chifukwa chiwerengero chabwino choyezetsa chakweranso kwambiri, kufika pa 20.3% kuyambira pa April 26. Izi zikutanthauza kuti matendawa awonjezeka.Poganizira kuti chiwerengero cha omwe adayezetsa sichinachuluke, anthu ambiri omwe ali ndi kachilombo alibe mwayi wopezeka.Zomwe zavumbulutsidwa pano ndi nsonga chabe ya madzi oundana.

Mliri wa kachilombo ka korona watsopano nthawi zonse wakhala lupanga la Damocles likulendewera pamitu ya anthu, ndipo chomwe chingalepheretse mliriwu ndikuzindikira.Mayeso atsopano a korona poyambilira adagwiritsa ntchito ukadaulo wa ma cell kuti azindikire ma nucleic acid a kachilomboka, koma tsopano akusintha pang'onopang'ono kugwiritsa ntchito nsanja yagolide ya colloidal kuti azindikire mapuloteni a antigen a kachilomboka.Chofunikira ndi kufunikira kwenikweni kwa msika.
Mbiri yakusintha pakuyesa korona wapadziko lonse lapansi
Nucleic acid kuzindikira nthawi
Mliri wa COVID-19 wakhala ukupitilira chaka chimodzi, ndipo lipoti la kafukufuku wa WHO lidati lipitiliza kusokoneza ntchito zachipatala m'maiko 90%.Ziribe kanthu momwe mayiko alili otsogola komanso otukuka, dongosolo lazachipatala la anthu komanso mabungwe asayansi aukadaulo omwe adamangidwa kale adangothandizira kuti apambane.Mayiko oyenerera monga United States, Germany, ndi Italy adawononga ndalama zambiri m'zipatala zokhala ndi ma square cabin, Malo opangira ma cell adamangidwa kuti apititse patsogolo luso lozindikira, adatengera njira zothandizira okalamba, ndikugwiritsa ntchito bwino zipatala zokwanira.Komabe, pakuchulukirachulukira kwa odwala komanso kufalikira kwathunthu kwa coronavirus yatsopano, mphamvu zachipatalazo zadzaza.
Mayiko otukuka ali otanganidwa kwambiri kuti adzisamalire, pamene mayiko omwe akutukuka kumene akukakamizika kwambiri ndi zifukwa zachuma za dziko ndipo sangathe kuyesa padziko lonse panthawi yake.WHO imawapatsa chithandizo chaukadaulo, maphunziro enieni, zida ndi zida kuti apititse patsogolo luso loyesa padziko lonse lapansi.Mwachitsanzo, COVID-19 itayamba kuoneka, Somalia inalibe luso loyesa ma cell, koma pofika kumapeto kwa 2020, Somalia ili ndi ma laboratories 6 omwe amatha kuyesa izi.
Komabe, izi sizingakwaniritsebe cholinga choti aliyense afufuze mozama.Panthawiyi, kuipa kwa nucleic acid kuzindikira kumawonekera:

*Mtengo wake ndi waukulu-mtengo wokwera wa zomangamanga za labotale, maphunziro a anthu ogwira ntchito, zida za labotale, zoyeserera zoyesa ndi zogwiritsidwa ntchito.Ndalamazi zatambasula kale machitidwe azachipatala a mayiko ambiri otukuka, ndipo mayiko omwe ali ndi ndalama zochepa komanso zapakati sangakwanitse.

*Ntchitoyi ndi yovuta ndipo imatenga nthawi yayitali.Ngakhale labotale ya mamolekyu a POCT idawonekera kale, nthawi yayitali kuti labotale wamba ya RT-pcr ipange zotsatira ndi pafupifupi maola 2.5, ndipo lipotilo liyenera kupezeka tsiku lotsatira.

*Laborator'malo ali ndi malire ndipo sangathe kufalikira madera onse.
*Wonjezerani chiopsezo chotenga matenda-mbali imodzi, ogwira ntchito zachipatala omwe akuyesa amawonjezera chiopsezo cha matenda, ndipo kuipitsidwa kwa labotale kudzasinthanso zitsanzo zina kukhala zolakwika ndikuyambitsa mantha;kumbali ina, anthu amayenera kupita ku chipatala kukayesa ma accounting.Pafupifupi kuchuluka kukhudzana ndi odwala zabwino kapena makulitsidwe nthawi, ndi chiopsezo cha matenda athanzi anthu komanso kuwonjezeka.

Nthawi yayifupi yoyesa ma antibodies
M'malo mwake, koyambirira kwa mliriwu, aliyense anali kuyesera kuchepetsa mtengo woyezetsa COVID-19, komanso kufewetsa njira zoyezera momwe angathere kuti achepetse ntchito ya ogwira ntchito zachipatala.Chifukwa chake, kuyesa kwa ma antibody ndiye njira yofulumira kwambiri yodziwira yomwe imatha kukhazikitsidwa papulatifomu yagolide ya colloidal.mimba.Koma chifukwa kuyesa kwa antibody ndikuyankha kwa chitetezo chamthupi thupi la munthu litatenga kachilombo katsopano, immunoglobulin IgM antibody imawonekera koyamba, yomwe imapangidwa mkati mwa masiku 5 mpaka 7;Kenako, ma antibody a IgG amawonekera, omwe amapangidwa m'masiku 10 mpaka 15.Nthawi zonse, ma antibodies a IgM amapangidwa msanga.Akadwala, amapangidwa msanga, amasungidwa kwakanthawi kochepa, ndipo amatha msanga.Kuyezetsa magazi kwabwino kungagwiritsidwe ntchito ngati chizindikiro cha matenda oyambirira.Ma antibodies a IgG amapangidwa mochedwa, amakhala kwa nthawi yayitali, ndipo amatha pang'onopang'ono.Mayeso abwino m'magazi angagwiritsidwe ntchito ngati chizindikiro cha matenda ndi matenda am'mbuyomu.

Ngakhale kuzindikirika kwa antibody kumathetsa zina mwazovuta za kuzindikira kwa nucleic acid, zimatengera nthawi yofikira kuti antigen ilowe m'thupi IgM ndi IgG isanapangidwe.Panthawi imeneyi, IgM ndi IgG sizingadziwike mu seramu, ndipo pali nthawi yazenera.Kuzindikira kwa ma antibody kuyenera kugwiritsidwa ntchito kuyesa kowonjezera kapena kuyesa kophatikizana kwa ma nucleic acid kwa odwala omwe akuganiziridwa kuti ali ndi zotsatira zoyesa za nucleic acid.

Pamene kuyeretsedwa kwa zida za antigen kumafika pamlingo komanso mphamvu zopangira zidalipo, kuzindikira kwa antigen kwayamba kugwiritsidwa ntchito kwambiri chifukwa ndizofanana ndi kuzindikira kwa nucleic acid pozindikira tizilombo tatsopano ta coronavirus ndipo palibe nthawi yazenera.

Kuzindikira kwa Antigen (Kugwiritsa Ntchito Mwaukadaulo).

Pambuyo pakubuka kangapo komanso kusintha kwatsopano kwa coronavirus yatsopano, imatha kukhala kachilombo komwe kamakhala ndi anthu kwanthawi yayitali ngati chimfine.Chifukwa chake, zida zatsopano zoyeserera za antigen zakhala "zokonda zatsopano" pamsika chifukwa cha ntchito yawo yosavuta, zotsatira zachangu, komanso mtengo wotsika.Pakuyesa magwiridwe antchito, chiphaso cha CE chokha ndichofunikira poyambira.Pambuyo pake, maiko aku Europe adatengera pang'onopang'ono kuyesa kwa antigen yatsopano ngati njira yowunikira, ndipo magwiridwe antchito adalimbikitsidwa.Madipatimenti azachipatala ndi azaumoyo ku Germany, United Kingdom, Belgium, Switzerland ndi mayiko ena ayambitsa ma laboratories oyamba apakati pa atatu omwe amatsimikizira magwiridwe antchito a opanga osiyanasiyana padziko lonse lapansi ndikuvomereza mwapadera.

▼Chithunzi chojambulidwa cha German Bfarm Special Approval Part
▼German PEI
▼Kuyesa kwa antigen mwachangu ku Belgium (katswiri wogwiritsa ntchito) zithunzi zovomerezeka zapadera
Zoonadi, kudziwika kwa ma antigen atsopano a korona kumatha kukhazikitsidwa pa nsanja ziwiri, imodzi ndi immunochromatography, yomwe nthawi zambiri timayitcha golide wa colloidal, yomwe imagwiritsa ntchito tinthu tating'onoting'ono ta golide kukulunga antigen antibody;ina ndi immunofluorescence, yomwe imagwiritsa ntchito latex.Ma Microspheres amaphatikiza ma antigen ndi ma antibodies.Poyerekeza ndi teknoloji ya immunochromatography, mtengo wa mankhwala a immunofluorescence ndi apamwamba.

1. Wowerengera wowonjezera wa fulorosenti amafunikira kuti atanthauzire.

2. Pa nthawi yomweyi, mtengo wa latex particles ndi wokwera mtengo kuposa golide

Kuphatikiza kwa Reader kumawonjezeranso zovuta zogwirira ntchito komanso kuchuluka kwa misoperation, zomwe sizothandiza kwa ogwiritsa ntchito wamba.

Kuzindikira kwa antigen kwagolide wa Colloidal golide kudzakhala chisankho chabwino kwambiri pamsika!
Wolemba: Do Laimeng K