Makasitomala a Sukulu ya Sayansi ya Moyo, Yunivesite ya Sichuan idasindikiza mapepala apamwamba kwambiri pogwiritsa ntchito zinthu za Foregene, zomwe zimakhudza 17.848

Posachedwapa, gulu la Song Xu lochokera ku School of Life Sciences ku Sichuan University lidasindikiza chikalata chamutu wakuti.Coagulation factor VII, IX ndi X ndi mapuloteni oletsa antibacterial motsutsana ndi mabakiteriya osamva mankhwala a Gram-negative mu Cell Research.

Cell Research ndi magazini yapadziko lonse lapansi yofalitsidwa pamodzi ndi Chinese Academy of Sciences ndi British Nature Publishing Group, yomwe ili yovomerezeka kwambiri pamaphunziro apamwamba.

Nkhaniyi itasindikizidwa, nthawi yomweyo idayambitsa chidwi m'masukulu.Pakadali pano, zotsatira za kafukufukuyu zalandiridwa ndi atolankhani ambiri monga Xinhua News Agency, World Wide Web, Phoenix Net, Southern Metropolis Daily,Biological Valley, British Daily Mail, American Daily Science, EurekAlert1!, Springer Nature, Phys.org, ndi zina zotero., BioMedCentral ndi magazini ena odziwika bwino ali ndi malipoti ochuluka, ndipo chidwi chapadziko lonse pa zotsatira zafukufukuzi chikukulirakulirabe.

Nkhaniyi inanena kuti zinthu zitatu za coagulation VII, IX ndi X zomwe zimagwira ntchito poyambitsa coagulation cascade ndi mtundu watsopano wa mapuloteni a antibacterial amkati, ndiko kuti, coagulation factor VII, IX ndi X ali ndi maudindo ofunikira mu ndondomeko ya coagulation.Angathenso kulimbana ndi mabakiteriya a Gram-negative, kuphatikizapo "mabakiteriya apamwamba" omwe sagonjetsedwa kwambiri monga Pseudomonas aeruginosa ndi Acinetobacter baumannii.

Song Xu, yemwe analemba nawo nkhaniyi, anati: “M'mbuyomu, anthu ambiri amakhulupirira kuti coagulation factor ingayambitse thrombosis, koma kafukufukuyu adawonetsa kuti coagulation factor imakhalanso ndi zotsatira zapadera za kulera.Aka ndi koyamba kupezeka kunyumba ndi kunja.”

Mbiri Yakufufuza

Monga tonse tikudziwira, kukana mabakiteriya kwakhala vuto lalikulu la thanzi la anthu padziko lonse lapansi.Zambiri zikuwonetsa kuti anthu pafupifupi 1 miliyoni amafa ndi matenda a mabakiteriya osamva mankhwala padziko lonse lapansi chaka chilichonse.Ngati palibe njira yabwinoko, chiwerengero cha anthu omwe amafa chaka chilichonse kuyambira 2050 chidzakhala 10 miliyoni.

Kugwiritsiridwa ntchito molakwika kwa maantibayotiki, limodzi ndi kuthekera kopambana kwa chisinthiko kwa mabakiteriya, kwapangitsa mabakiteriya ena omwe akanatha kuphedwa ndi mankhwala opha mabakiteriya kukhala osamva mankhwala, kukhala "mabakiteriya apamwamba" osatha.

Kuphatikiza apo, poyerekeza ndi mabakiteriya a Gram-positive (Gram+), mabakiteriya oyipa (Gram-) ndi ovuta kupha chifukwa cha kupezeka kwa nembanemba yakunja (gawo lalikulu ndi LPS, alias endotoxin, lipopolysaccharide).Nembanemba yakunja ndi envulopu yopangidwa ndi nembanemba ya mkati mwa cell, khoma la cell yopyapyala ndi nembanemba yakunja ya cell.

Mbiri ya kafukufuku

Gulu la a Song Xu lidaphunzira momwe zimakhudzira ma coagulation pochiza zotupa zowopsa, koma mu 2009, mosayembekezereka zidadziwika kuti coagulation factor imatha kupha mabakiteriya.Pofuna kufotokozera njira ya bactericidal ya coagulation factor, ntchitoyi yakhala zaka 10 kuyambira pachiyambi cha kafukufuku mpaka kusindikizidwa kwa pepala.

Zapezeka mwangozi

Mu 2009, ofufuza adapeza mwangozi kuti coagulation factor VII imatha kulimbana ndi Escherichia coli pakati pa zinthu zopitilira khumi ndi ziwiri.

Escherichia coli ndi mabakiteriya a gram-negative mu mabakiteriya.Mabakiteriya amtunduwu ndi ovuta kuthana nawo, chifukwa maselo awo ali ndi nembanemba ya mkati mwa selo, khoma laling'ono la selo ndi khungu lakunja.Envulopuyo imatha kuletsa mankhwalawo ndikuteteza mabakiteriya kuti "asalowe."

Lingalirani zongoganiza

Coagulation factor ndi gulu la mapuloteni omwe ali m'magazi omwe amakhudzidwa ndi kutsekeka kwa magazi.Pamene kuvulala kwa thupi la munthu kumayambitsa magazi, zinthu zosiyanasiyana za coagulation zimayambika pang'onopang'ono kupanga fibrin filaments, yomwe imasindikiza bala pamodzi ndi mapulateleti.Ngati chimodzi kapena zingapo za coagulation zikusowa, zovuta za coagulation zimachitika.

Asayansi awona kuti odwala coagulopathy nthawi zambiri amakhala ndi matenda a bakiteriya monga sepsis ndi chibayo.Kulumikizana kumeneku kunawapangitsa kuganiza kuti zinthu za coagulation sizingangogwira ntchito yofunika kwambiri mu ndondomeko ya coagulation, koma zingakhalenso ndi anti-infection effect.

Kuphunzira mozama

Pofuna kufufuza ngati coagulation factor ingathe kuthana ndi mitundu yambiri ya mabakiteriya a Gram-negative, ochita kafukufuku anayamba kufufuza mozama njira yake ya antibacterial.Adapeza kuti coagulation factor VII ndi zinthu zofananira IX ndi factor X, mapuloteni atatuwa amatha kudutsa muvulopu yolimba ya mabakiteriya opanda gram.

Zinthu zambiri zolimbana ndi mabakiteriya zomwe zilipo zimayang'ana kagayidwe ka cell kapena nembanemba zama cell, koma zinthu zitatuzi zomwe zimaphatikizana zimakhala ndi machitidwe osiyanasiyana.Iwo akhoza hydrolyze LPS, chigawo chachikulu cha bakiteriya kunja nembanemba.Kutaya LPS kumapangitsa kuti zikhale zovuta kuti mabakiteriya a Gram-negative apulumuke.

Pitani patsogolo

Gulu lofufuza lidafufuzanso makinawo ndikupeza kutimapuloteni a coagulation factor amagwira mabakiteriya kudzera mu gawo lake la unyolo wopepuka, pomwe gawo lolemera la unyolo lilibe antibacterial effect.

M'malo a chikhalidwe cha ma laboratory, ofufuzawo adawona momveka bwino kuti atawonjezera coagulation factor kapena zigawo zake zowunikira, envelopu ya cell ya bakiteriya idawonongeka poyamba, ndiyeno mkati mwa maola 4, selo lonse la bakiteriya linali pafupifupi kuwonongedwa kwathunthu.

Onjezani gawo la factor VII launyolo ku Escherichia coli yotukuka,

Zigawo za bakiteriya kunja kwa nembanemba zimawonongeka, maselo amawonongeka

Osati Escherichia coli yokha, komanso mabakiteriya ena a Gram-negative omwe anayesedwa "anagonjetsedwa", kuphatikizapo Pseudomonas aeruginosa ndi Acinetobacter baumannii.Mabakiteriya onsewa adalembedwa ndi World Health Organisation (WHO) ngati mabakiteriya 12 omwe amawopseza kwambiri thanzi la munthu chifukwa chakusamva mankhwala.

Kutsimikizira koyeserera

Zoyeserera zotsatirazi za nyama zidatsimikiziranso mphamvu ya zinthu zoundana motsutsana ndi mabakiteriya apamwamba.

Ofufuzawo analowetsa mbewa ndi chiwerengero chachikulu cha Pseudomonas aeruginosa kapena Acinetobacter baumannii osamva mankhwala.Pambuyo jekeseni mlingo waukulu wa factor VII kuwala unyolo, mbewa anapulumuka;pamene mbewa mu gulu lolamulira jekeseni ndi saline wabwinobwino anali 24 Onse anafa ndi matenda pambuyo pa maola.

Pambuyo pa matenda ndi mabakiteriya apamwamba, kulowetsedwa kwa Factor VII light chain

Itha kugwira ntchito yoteteza ndikuwongolera kwambiri kuchuluka kwa mbewa

Kufunika

Pakadali pano, palibe mankhwala oletsa mabakiteriya omwe amadziwika kuti amagwira ntchito ndi hydrolyzing LPS.

Kufotokozera njira ya antibacterial yochokera ku LPS hydrolysis ndi zizindikiro za antibacterial za coagulation factor, kuphatikiza ndi kuthekera kopanga zinthu za coagulation izi pamlingo waukulu pamtengo wotsika, zitha kupereka njira yatsopano yotsika mtengo yolimbana ndi mabakiteriya osamva mankhwala a Gram-negative Vuto ladzidzidzi laumoyo wa anthu linayambitsa.

Kuphatikiza apo, ntchitoyi imakhalanso ndi chiyembekezo chogwiritsa ntchito kwambiri pazachipatala.Pakadali pano, palibe mankhwala odziwika bwino oletsa mabakiteriya omwe amagwira ntchito ndi hydrolyzing LPS.Kuphatikiza ma antibacterial properties a FVII, FIX, ndi FX motsutsana ndi LPS ndi kupanga zotsika mtengo kwambiri, akuyembekezeka kupanga mankhwala atsopano motsutsana ndi matenda a "mabakiteriya apamwamba".

Kuwonjeza mutu

Ngakhale kuti anthu amadziwa bwino dzina la "mabakiteriya apamwamba", mawu awo olondola ayenera kukhala "mabakiteriya osamva mankhwala ambiri", omwe amatanthauza mtundu wa mabakiteriya omwe sagonjetsedwa ndi ma antibiotic angapo.

Monga tanena kale, kuchulukirachulukira kwa mabakiteriya kumayamba chifukwa chogwiritsa ntchito molakwika kapenanso nkhanza za maantibayotiki.Mwachitsanzo, kugwiritsa ntchito pafupipafupi kwa maantibayotiki ambiri pochiza matenda am'mimba.

Matenda a m'mapapo ndi matenda omwe tonse timawadziwa.Malinga ndi ziwerengero, mwana aliyense amatenga kachilombo ka 6 mpaka 9 pachaka, ndipo achinyamata ndi akuluakulu amadwala pafupifupi 2 mpaka 4 pachaka.

Chifukwa chakuti matenda opuma kupuma nthawi zambiri amakhala madipatimenti adzidzidzi, vuto lalikulu kwa madokotala odzidzimutsa pamene akukumana ndi odwala ndikuti sangathe kupeza chidziwitso cha pathogenic mu nthawi yochepa.Chifukwa chake, kuchepa kwa mayeso a pathogenic kumapangitsa madokotala kuti agwiritse ntchito maantibayotiki ambiri (omwe amatha kukhala othandiza).Kwa mitundu yambiri ya mabakiteriya).

Njira yamankhwala imeneyi ndi “yofalitsira kwambiri” imene yachititsa kuti pakhale vuto lalikulu losamva mabakiteriya.Chifukwa chakuti mitundu yambiri ya tizilombo tosamva bwino ikaphedwa mosalekeza, mitundu yosamva mankhwala imachulukana m'malo mwa tizilombo tomva ululu, ndipo chiwopsezo cha mabakiteriya olimbana ndi mankhwalawa chidzapitirira kukwera.

Choncho, ngati lipoti lolondola lodziwika bwino la tizilombo toyambitsa matenda lingapezeke pakanthawi kochepa kuti liwatsogolere madokotala popereka mankhwala oyenera, kugwiritsa ntchito mankhwala opha tizilombo tosiyanasiyana kungachepetsedwe kwambiri, motero kuchepetsa vuto la kukana kwa mabakiteriya.

Poyang'anizana ndi vutoli, gulu lofufuza za sayansi la Fuji linayamba kupanga zida 15 zodziwira tizilombo toyambitsa matenda.

Chidachi chimatengera kuphatikiza kwaukadaulo wa Direct PCR ndi multiplex PCR, womwe umatha kuzindikira Streptococcus pneumoniae, Staphylococcus aureus yosamva methicillin, Haemophilus influenzae ndi mathirakiti ena 15 odziwika bwino opumira mu sputum pafupifupi ola limodzi.Mabakiteriya a pathogenic amatha kusiyanitsa bwino pakati pa mabakiteriya okhala ndi colonizing (mabakiteriya wamba) ndi mabakiteriya a pathogenic.Ndikukhulupirira kuti chikuyembekezeka kukhala chida chothandiza othandizira azachipatala kugwiritsa ntchito bwino mankhwala.

Pamaso pa "mabakiteriya apamwamba", mdani wapagulu wa anthu onse, anthu sanatengepo mopepuka.Pankhani ya sayansi ya moyo, pali ofufuza ambiri ngati gulu la Song Xu omwe akugwira ntchito mwakhama kuti afufuze ndikugwira ntchito mwakachetechete pamsewu kuti apeze mayankho a "mabakiteriya apamwamba".

Pano, m'malo mwa anzawo achilengedwe komanso opindula, Fortune Biotech ikufuna kupereka ulemu waukulu kwa asayansi onse omwe adzipereka ndi thukuta pa izi, ndikupempheranso kuti anthu athe kugonjetsa "mabakiteriya apamwamba" posachedwa ndikukhala ndi moyo wotetezeka komanso wathanzi.malo ozungulira.