Malinga ndi ziwerengero za Zhiliwo Big Data Platform, chiwopsezo chapakati chotchulira mapepala a Foregene SCI mu February 2022 ndi okwera mpaka 5.8, ndipo chiwopsezo chachikulu ndi 8.947.
Kupyolera mu kusanthula kwa chiwerengero cha mapepala a SCI a zinthu za Foregene pazaka zambiri, zikuwonekeratu kuti kukula kwake ndi koonekeratu.
Foregene Co., Ltd. idakhazikitsidwa mchaka cha 2011. Ndi bizinesi yaukadaulo yazachilengedwe kuphatikiza R&D, kupanga, malonda ndi ntchito zamakasitomala.Chiyambireni kukhazikitsidwa kwake, yakhala ikuyang'ana kwambiri pakupanga matekinoloje okhudzana ndi ma cell ndi ma cell biology, zogulitsa ndi ntchito, ndikupereka kuyeretsa kwa nucleic acid, kuzindikira kwa nucleic acid ndi mayankho ena kwa ogwiritsa ntchito ambiri.Mzere wake wazofufuza zasayansi umaphatikizapo kuyeretsa kwa RNA, mndandanda woyeretsa DNA, mndandanda wa RT/RT-PCR, mndandanda wa PCR wolunjika, mndandanda wa PCR Mix, mndandanda wachindunji wa RT-qPCR ndi "Sui" zida zogwirizana ndi mamolekyulu.Zogulitsa zakhala zikugwiritsidwa ntchito kwambiri pakufufuza koyambira mu sayansi ya moyo, zamankhwala, ulimi, mankhwala, ndi chilengedwe.Makasitomala ali m'mayunivesite, mabungwe ofufuza, zipatala ndi mayunitsi ena.
ZhiLiaowo wasankha zikalata 6 zapamwamba kwambiri za Foregene mu February kuti afotokozere ofufuza, kuti athe kumvetsetsa mozama komanso kuzolowera zinthu za Foregene.
Mutu wankhani: Kuuma kwa gawo lapansi kumayang'anira kusiyanitsa kwa ma cell opangidwa ndi pluripotent tsinde kukhala ma cell endothelial amtima
DOI: 10.1016/j.actbio.2022.02.032
Nthawi yotulutsidwa: 2022-2-27
Foregene
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Mutu wa Nkhani: Kuzindikira Zomwe Zingatheke Mitochondrial Proteome Signature Zogwirizana ndi Pathogenesis ya Pulmonary Arterial Hypertension mu Rat Model
DOI: 10.1155/2022/8401924
Nthawi yotulutsidwa: 2022-2-21
Author Affiliation: Dipatimenti ya Pharmacy, First Affiliated Hospital ya Xinjiang Medical University.
Chidziwitso: Pulmonary arterial hypertension (PAH) ndi matenda oopsa komanso opita patsogolo omwe amakhudza mtima ndi mapapo ndipo ndi vuto lapadziko lonse lapansi lomwe limakhudza anthu ndi anthu.Mu phunziro ili, chitsanzo cha makoswe cha PAH chopangidwa ndi monocrotaline (MCT) chinamangidwa bwino.Mapuloteni a mitochondrial a gulu lililonse la makoswe adatsimikiziridwa pogwiritsa ntchito njira zopanda malembo zochulukirachulukira za proteinomic.Kutengera ntchito yomanga ndi kukulitsa magwiridwe antchito a ma protein-protein interaction (PPI), ma gene 19 otsogola a mitochondrial ndi ma 123 a mitochondrial omwe amawongolera makoswe adawonetsedwa mu makoswe a PAH.Kuphatikiza apo, pakuyesa kodziyimira pawokha kwa dataset, zotsatira zake zidawonetsa kuti ma jini a 6 otsogola a mitochondrial ndi ma 3 otsika a mitochondrial adawonetsedwa mosiyanasiyana m'mapapo a makoswe a PAH.Ma jini apakati a mitochondrial omwe amatha kutsata miRNA adanenedweratu pamlingo wa transcriptome pogwiritsa ntchito nkhokwe ya RNAInter.Kafukufukuyu adawonetsanso kuti bortezomib ndi carfilzomib ndi mankhwala omwe angathe kuchiza PAH.Pomaliza, phunziroli likupereka kuwala kwatsopano pa ma biomarkers ndi njira zochiritsira za PAHs.
Foregene
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RT Easy II (Master Premix for First Strand cDNA Synthesis For qPCR)
Mbiri ya RT-01021
Kufotokozera: 50 × 10 μL rxns
Mutu wa Nkhani: Kutayika kwa PTEN kumapereka chidwi kwa ma rapalogs mu cell renal cell carcinoma
DOI: 10.1038/s41401-022-00862-1
Nthawi yotulutsidwa: 2022-2-14
Author Affiliation: Dipatimenti ya Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, China
Zachidule: Rapalog ndi allosteric mTORC1 inhibitor komanso mankhwala ovomerezeka a advanced clear cell renal cell carcinoma (ccRCC).Kafukufuku wogwiritsa ntchito ma cell a ccRCC opangidwa ndi odwala angapo akuwonetsa kuti ma cell omwe alibe PTEN amawonetsa hypersensitivity kwa ma rapalog.M'mizere ya cell ya PTEN ccRCC yoperewera, ma Rapalogs adaletsa kuchulukana kwa maselo poyambitsa kumangidwa kwa G0/G1 popanda kuyambitsa apoptosis.Pogwiritsa ntchito CRISPR/Cas9 yopangidwa ndi ma cell a isogenic, kafukufukuyu adatsimikizira mgwirizano pakati pa kuchotsedwa kwa PTEN ndi Rapallo hypersensitivity.Mosiyana ndi izi, kufufutidwa kwa VHL kapena jini yosinthira chromatin (PBRM1, SETD2, BAP1, kapena KDM5C) sikunakhudze mayankho amtundu wa ma rapalogs.Mawonekedwe a Ectopic a activated mTOR mutant (C1483F) adawonetsedwa kuti athane ndi PTEN-induced cell growth inhibition, pomwe kuyambitsidwa kwa mankhwala osamva mankhwala a mTOR mutant (A2034V) amalola ma cell a PTEN-deficie ccRCC kuthawa zotsatira zopondereza za rapalogs.Maselo a PTEN omwe alibe ccRCC anali okhudzidwa kwambiri ndi zolepheretsa za temsirolimus pa kusamuka kwa maselo ndi kukula kwa chotupa mu zebrafish ndi mbewa za xenograft.Kafukufuku wasonyeza kuti kuchotsedwa kwa PTEN kumagwirizanitsidwa ndi kukhudzidwa kwa rapallo ndipo kungagwiritsidwe ntchito ngati chizindikiro cha kusankha mankhwala a rapallo mwa odwala ccRCC.
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Mutu wankhani: Mphamvu yamphamvu ya microbiota yamadzi amchere amchere amchere okhala ndi yisiti yololera mchere komanso kugwiritsa ntchito kwake.
DOI: 10.1016/j.jece.2022.107377
Nthawi yotulutsidwa: 2022-2-12
Wolemba: School of Life Sciences, Jiangxi Normal University
Tanthauzo: Madzi otayira amchere okhala ndi mchere wambiri ndi madzi otayira m'mafakitale okhala ndi zigawo zovuta, kusawonongeka kwachilengedwe komanso chithandizo chovuta chamankhwala.Pofuna kuwulula momwe zimakhalira m'magulu a tizilombo tating'onoting'ono tomwe timagwiritsa ntchito madzi onyansa a mchere wambiri ndi yisiti yolekerera mchere, kafukufuku wokhudzana ndi tizilombo toyambitsa matenda komanso zachilengedwe anachitidwa.Miyezo yochotsa kufunikira kwa okosijeni wamankhwala, NH3-H ndi nayitrogeni yonse idasinthidwa kwambiri mu WWTP yoyendetsa ndege.Zotsatira zakuchulukirachulukira zidawonetsa kuti biofortification idakhudza kwambiri mapangidwe ammudzi.Pa mlingo wa phylum, magulu a Proteobacteria ndi Ascomycota ndi omwe amatsogolera, pamene pamtundu wamagulu magulu a Paracoccus ndi Meyeroi amatsogolera.Meyerella amatenga gawo lofunikira pakuchiritsa kwamadzi amchere amchere amchere, zomwe zitha kukhala chifukwa chachikulu chothandizira kuchotsa zowononga.Kuphatikiza apo, pH, okosijeni wosungunuka, ndi kuchuluka kwamphamvu zinali zinthu zazikulu zomwe zimakhudza kutsatizana kwamagulu a tizilombo toyambitsa matenda panthawi ya bioaugmentation, komabe, kuchuluka kwa Meyerrotheca sikunakhudzidwe ndi kuchuluka koyipa koyipa.Kafukufukuyu adavumbulutsa mwadongosolo kusintha kwamphamvu komanso kuneneratu kogwira ntchito kwa tizilombo tating'onoting'ono panthawi ya bioaugmentation, komanso ubale wapakati pamagulu ang'onoang'ono ndi zinthu zachilengedwe, ndikuyika maziko olimba amalingaliro otsatiridwa pambuyo pake amadzi otayira amchere komanso amchere wambiri.
Foregene
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Mutu wa Nkhani: Multi-Omics Analysis After Vaginal Administration of Bacteroides fragilis in Chickens.
DOI: 10.3389/fmicb.2022.846011
Nthawi yotulutsidwa: 2022-2-16
Author Affiliation: Sichuan Key Laboratory of Agricultural and Animal Genetic Resources Development and Innovation
Ndemanga: Njira yoberekera ya nkhuku ndi chiwalo chofunikira kwambiri pakupanga dzira.Kulumikizana kwapafupi pakati pa nyini ndi chilengedwe chakunja kungayambitse kuukira kwa mabakiteriya osiyanasiyana a pathogenic, kumakhudza mkati ndi kunja kwa mazira, komanso kuonjezera chiwerengero cha imfa ndi kuwononga chuma.M'zaka zaposachedwa, ma probiotics abweretsa phindu pazachuma ku ziweto ndi nkhuku monga njira ina yopangira maantibayotiki.Zotsatira za ukazi wa B. fragilis pa nkhuku cloacal microbiota, transcriptome ya vaginal ndi metabolome adafufuzidwa kuti awone ubwino wa B. fragilis.Zotsatira zinasonyeza kuti chithandizo cha B. fragilis chinakhudza tizilombo toyambitsa matenda a cloaca.Kusanthula kwa Transcriptome kunapeza kuti majini okhudzana ndi chitetezo cha mthupi CCN3, HAS2, ndi RICTOR anali okhazikika, ndipo majeremusi otupa a EDNRB, TOX, ndi NKX2-3 anali otsika, ndipo DEGs adalimbikitsidwanso pakuwongolera kutupa, ma cell metabolism, ndi njira zoyankhira za synaptic.Kuphatikiza apo, ma metabolites osiyanitsa anali makamaka okhudzana ndi steroid hormone biosynthesis, unsaturated fatty acid biosynthesis, ndi arachidonic acid metabolism, ndipo kafukufuku adapeza mayanjano pakati pa ma metabolites apadera ndi majini.Pomaliza, phunziroli limapereka maziko amalingaliro ogwiritsira ntchito B. fragilis ngati probiotic yomwe ingakhalepo pa ziweto ndi nkhuku.
Foregene
Literature Cited Products
RT Easy II (Master Premix for first strand cDNA synthesis for qPCR)
Nambala yagulu: RT-01031
Kufotokozera: 25 × 20 μL rxns
Mutu wankhani: Mitundu yosiyanasiyana ya Echinococcus granulosus sensu lato ku China: Maphunziro a Epidemiological ndi kuwunika mwadongosolo
DOI: 10.1111/tbed.14469
Nthawi yotulutsa: 2022-2-9
Author Affiliation: Sichuan Key Laboratory of Agricultural and Animal Genetic Resources Development and Innovation
Chidziwitso: Cystic echinococcosis (CE) ndi matenda osasamalidwa a zoonotic omwe amayamba chifukwa cha Echinococcus granulosus ndipo akadali vuto lalikulu lazaumoyo padziko lonse lapansi.Ma genotype omwe alipo odziwika a Echinococcus granulosus kupatula G4 adziwika ku China, makamaka ku Qinghai-Tibet Plateau, ndipo mitundu yawo yamitundu yosiyanasiyana ndi yapadera kudera lino ladziko lapansi.Malinga ndi ndondomeko ya ndondomeko, chibadwa cha E. granulosa m'dziko langa ndi motere: E. granulosa (G1, G3), 98,3%;Echinococcus intermedius (G5), 0,1%;Echinococcus intermedius (G6, G7), 1,4%;ndi Canada Echinococcus (G8, G10), 0.2%.Mwachindunji, chiwopsezo cha matenda a G1 chinali 97.7% ndipo chimadziwika ndi kuchuluka kwa anthu omwe akukhala nawo komanso kugawa kwawo.Zotsatira za Epidemiological zidawonetsa kukhazikika komanso kosalala bwino kwa jini ya E. coli mu nkhosa ndi yak kuchokera ku zigawo zitatu za CE zomwe zafala kwambiri (Xinjiang, Sichuan, ndi Qinghai).Nkhosa (287/406, 70.7%) zinali ndi gawo lalikulu la zotupa zachonde kuposa yak (28/184, 15.2%).Pazaka 29 zapitazi, pakhala pali mitundu 51 ya Echinococcus granulosus cox1 haplotypes ku China.Ma haplotype a makolo (Hap_2) adakhalabe odziwika kwambiri, ma haplotype 12 odziwika bwino anali ofala, ndipo ma haplotype 9 omwe adanenedwa kumene adadziwika panthawi ya kafukufukuyu.Zomwe zapezazi zikusonyeza kuti katemera wovomerezeka wa nkhosa ndi kampeni yoyendetsa katemera wa EG95 ya yaks ikugwirizana kwambiri ndi momwe genotype ilipo.
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Maggie |Kupititsa patsogolo Bizinesi
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M: +86-15281067355
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Nthawi yotumiza: Apr-08-2022
